Prellis Biologics uses proprietary technology to 3D print lymph node organoids, which we are using to generate in vitro antibody libraries andinvitrohumanlymphnodecoculturesfor generating antigen-specific B-cells.We are seeking a highly motivated Associate Scientist – Senior Associate Scientist, Cell-Based Assays, to join our Antibody Screening team. The successful candidate will support and advance antibody discovery programs through development and execution of robust cell-based binding and functional assays.This role will play a key part in establishing, optimizing, and operationalizing diverse assay formats to enable screening of large antibody panels against a diverse class of targets.The successful candidate will contribute across the full workflow, from cell line generation and assay development to high-throughput screening and data analysis, and will work closely with cross-functional discovery teams.

Key Responsibilities:

• Design, develop, optimize, and execute on-cell binding assays (e.g., flow cytometry, imaging-based, receptor internalization, competition formats) to evaluate antibody binding to native target conformations.
• Establish and run functional assays relevant to mechanism of action, including but not limited to: receptor signaling, internalization assays, blocking/competition assays, reporter-based pathway activation assays.
• Adapt assays for medium to high-throughput screening of large antibody panels, including primary screening and secondary confirmation formats.
• Transfer and scale assays from development to routine screening, ensuring robustness, reproducibility, and suitability for automation.
• Execute high-throughput antibody screening campaigns, including assay setup, sample handling, data acquisition, and preliminary analysis.
• Perform routine mammalian cell culture, including maintenance, expansion, cryopreservation, and quality control of multiple adherent and suspension cell lines.
• Maintain meticulous experimental records and effectively communicate findings in internal meetings.
• Minimum Qualifications:
• B.S in Biology, Chemistry, Immunology, Biotechnology, or related life science field with 5+ years of relevant experience, or M.S. with 3+ years of relevant experience in antibody discovery, cell biology, or assay development.
• Hands-on experience with cell-based binding assays (e.g., flow cytometry, imaging, ligand-receptor interaction assays).
• Demonstrated experience developing and running functional assays for biologics (signaling, internalization, blocking, effector function, reporter assays).
• Familiarity with high-throughput screening environments and automated liquid handling is a plus.
• Strong organizational and time management skills to contribute to multiple projects in a fast-paced environment.
• Ability to work independently and as part of a collaborative team.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.