The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications. To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

We are seeking a talented and motivated Senior Scientist to join our Antibody Engineering Department, specializing in the development of purification methods for bispecific and other engineered antibody formats. The successful candidate will lead the development and optimization of both small-scale and large-scale purification workflows to support candidate screening, format characterization, and early-stage developability evaluations.

Key Responsibilities:

• Develop and optimizepurification methods for bispecific and engineered antibodies using Protein A, ion exchange (IEX), hydrophobic interaction chromatography (HIC), and size exclusion chromatography (SEC).
• Execute purification workflows using ÄKTA™ avant chromatography systems to support screening of antibody candidates from transient mammalian expression systems (e.g., HEK293, CHO).
• Implement and maintain high-throughput purification workflows to support early-stage format assessment and developability profiling
• Perform protein characterization using SDS-PAGE, analytical SEC (for aggregation analysis).
• Conduct endotoxin testing on purified materials to ensure suitability for downstream applications, including in vitro and in vivo studies.
• Interface with Antibody Engineering scientists to evaluate purification behavior and developability risks of novel antibody constructs.
• Document all purification methods, experimental results, and analysis in electronic lab notebooks and technical reports.

Qualifications

• Ph.D. in Biochemistry, Chemical Engineering, Biotechnology, or related field with 3+ years of relevant industry experience; or M.S. with 8+ years in protein purification or biologics development.
• Extensive hands-on experience with purification of bispecific antibodies or other complex antibody modalities.
• Expertise using ÄKTA™ avant chromatography systems and Unicorn software for method development and optimization.
• Proficiency in chromatography techniques such as Protein A, IEX, SEC, and HIC.
• Experience with analytical tools including SDS-PAGE, analytical SEC, UV spectroscopy, and endotoxin measurement techniques (e.g., LAL assay, EndoSafe).
• Strong understanding of antibody structure and common developability challenges such as aggregation, mispairing, and heterogeneity.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before. Prellis Biologics is a pre-IPO biotech located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and oncology disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners.

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A competitive employee benefits package, including group medical, dental and vision coverage, life and disability insurance, flexible spending accounts an a 401(k) plan
• Stock-based long term incentives
• Bonus plan
• Holiday package including a 1+ week winter shutdown
• Flexible work models, including remote and hybrid working arrangements, where possible

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.